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Lysergic acid diethylamide (also known as Lysergide, LSD-25, LSD, L, Lucy,and Acid) is a widely used semisynthetic psychedelic substance of the lysergamide class that produces classical, psychedelic effects when administered. LSD was first synthesized by the Swiss chemist Albert Hofmann in 1938, butits mind altering properties were not discovered until 1943. In 1947, itwas introduced as a commercial medication under the trade-name Delysid foruse in clinical psychiatry and research.
How it Came about
Following its release, LSD had a major impact on scientific research and psychiatry. Within 15 years, research on LSD and other hallucinogens generated over 1,000 scientific papers and was prescribed to over 40,000 patients. During this time, it was investigated by the U.S. Central Intelligence Agency (CIA) as a potential mind control agent in a clandestine project named MK-ULTRA. Its widespread adoption by the Western counterculture in the 1960s eventually resulted in its global prohibition in 1971.
Nevertheless, unpredictable adverse reactions such as uncontrollable anxiety, delusions and psychosis can always occur, particularly among those who are predisposed to mental disorders. LSD structure contains a bicyclic hexahydroindole ring fused to a bicyclic quinoline group (lysergic acid). At carbon 8 of the quinoline anN, generally N-diethyl carboxamide is bound, LSD is additionally substituted at carbon 6 with a methyl group. LSD is a chiral compound with two stereocenters at R5 and R8. LSD, also called (+)-D-LSD, has an absolute configuration of (5R, 8R). The three other stereoisomers of LSD do not have psychoactive properties.