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Methoxetamine, abbreviated as MXE, is a dissociative hallucinogen that has been sold as a designer drug. It differs from many dissociatives such as ketamine and phencyclidine that were developed as pharmaceutical drugs for use as general anesthetics in that it was designed for grey market distribution.
Methoxetamine is a near chemical analog of ketamine and P*****. Its use was first publicly reported in 2010. MXE is an arylcyclohexylamine. It acts mainly as a selective NMDA receptor antagonist, similarly to other arylcyclohexylamines like ketamine and P*****. 3-MeO-2′-Oxo-PCE (commonly known as Methoxetamine, MXE, Mexxy, among others) is a dissociative substance of the arylcyclohexylamine class that produces ketamine-like dissociative effects when administered.
It is structurally related to ketamine,buy methamphetamine online Buy MXE Online MXE is an arylcyclohexylamine. It is a derivative of eticyclidine (PCE) and 3-methoxyeticyclidine (3-MeO-PCE) and is also known as 3-methoxy-2′-oxo-PCE. It is closely related structurally to ketamine, and more distantly to P*****. MXE is reported to have a similar effect to ketamine, with increased potency and duration. It was often believed to possess opioid properties due to its structural similarity to 3-HO-P*****, but this assumption is not supported by data, which shows insignificant affinity for the ?-opioid receptor by the compound. Recreational use of MXE has been associated with hospitalisations from high and/or combined consumption in the US and UK. Acute reversible cerebellar toxicity has been documented in three cases of hospital admission due to MXE overdose, lasting for between one and four days after exposure.
MXE may be an effective, fast-acting antidepressant like ketamine.